I’m not sure when the idea of “human enhancement” first bubbled up in my brain. It seems to be one of those possibilities which I just grew up with, thanks to a childhood lost in books. In Cosmos, Carl Sagan wrote,
There must be ways of putting nucleic acids together that will function far better — by any criterion we choose — than any human being who has ever lived. Fortunately, we do not yet know how to assemble alternative sequences of nucleotides to make alternative kinds of human beings. In the future we may well be able to assemble nucleotides in any desired sequence, to produce whatever characteristics we think desirable — a sobering and disquieting prospect.
The video version ends with “awesome and disquieting prospect,” by the way. Sagan’s friend Isaac Asimov was a little more cheerful; while dying of AIDS, he concluded the revision of his book The Human Brain with these words:
Man would then, by his own exertions, become more than man, and what might not be accomplished thereafter? It is quite certain, I am sure, that none of us will live to see the far-distant time when this might come to pass. And yet, the mere thought that such a day might some day come, even though it will not dawn on my own vision, is a profoundly satisfying one.