Here is physicist John Archibald Wheeler, interviewed in the documentary The Creation of the Universe (1985):

There’s nothing deader than an equation. You write that down in a square on a tile floor. And on another tile on the floor you write down another equation, which you think might be a better description of the Universe. And you keep on writing down equations hoping to get a better and better equation for what the Universe is and does.

And then, when you’ve worked your way out to the end of the room and have to step out, you wave your wand and tell the equations to fly.

And not one of them will put on wings and fly.

Yet the Universe flies!

It has a life to it that no equation has, and that life to it is a life with which we are also tied up.

I saw that documentary as a kid, and that little speech was one part that stuck with me ever after. For the story of how Wheeler made this point to his physics classes, see arXiv:1405.2390, page 292.